
Interaction between various cultures created turning points in North Dakota. The Metis of the northern Red River Valley created a new culture between Native Americans and European fur traders. The Selkirk Colony, also of the northern Red River Valley, was a settlement of Scots and Irish, who also created a turning point by introducing even more non-Indians into the area. Missionaries came to North Dakota during the early fur trading era and introduced Native Americans to a new religion. When the non-Indians came to the land, they also introduced different diseases that Native Americans had never come in contact with before. Smallpox was one of those diseases. This disease would decimate tribes that remained along the Missouri River, causing a turning point for both non-Indians and Native Americans.
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